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Somatostatin Analogues

What are somatostatin analogues?

Somatostatin is a protein made naturally in the body by

  • A gland in the brain (hypothalamus)
  • The stomach
  • The pancreas
  • The bowel

Somatostatin does several things

  1. Reduce the hormone production
  2. Slows down the emptying of the stomach and bowel
  3. Controls the release of hormones made by the pancreas, including insulin
  4. Slows down or stops the release of growth hormones

Somatostatin analogues such as daily octreotide injections or long-acting preparations such as Sandostatin LAR or Lanreotide Autogel given monthly are very useful for controlling the symptoms of hormone release by carcinoid or pancreatic NETs. They may have an anti-tumour effect at a higher dose.

Ref: Cancer Research UK

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